Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Molecular Reproduction and Development Année : 2014

Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells

Résumé

Thyroid hormone is required for the timely transition of Sertoli cells from proliferative to differentiating and maturing. This transition takes place during a critical developmental period in mammals, which in mice is the first post-natal week. In order to identify the underlying molecular mechanisms of this differentiation process, we used Cre/loxP technology to selectively block the function of the thyroid hormone receptor TR1 in Sertoli cells. We then used RNA-seq to analyze the changes in gene expression induced in the post-natal testis. This differential analysis provides genetic clues to the initial testicular defects resulting from disrupted thyroid hormone signaling, and suggests that Sertoli cells influence germ cells soon after their birth.

Domaines

Autre [q-bio.OT]

Dates et versions

hal-01130502 , version 1 (11-03-2015)

Identifiants

Citer

Fabrice Chatonnet, Gabriel Livera, Betty Fumel, Sophie Fouchécourt, Frederic Flamant. Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells. Molecular Reproduction and Development, 2014, 81 (12), pp.1159 - 1166. ⟨10.1002/mrd.22437⟩. ⟨hal-01130502⟩
154 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More