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Article Dans Une Revue Current HIV Research Année : 2012

Structural basis of tetherin function.

Résumé

HIV-1 employs its structural proteins to orchestrate assembly and budding at the plasma membrane of host cells, which depends on numerous cellular factors. Although cells evolved interferon inducible restriction factors such as tetherin that act as a first line of defense, enveloped viruses, including HIV-1, developed countermeasures in the form of tetherin antagonists such as Vpu that decrease the effect of tetherin and permits normal viral replication in vivo. Here we review recent advances in the understanding of the dynamic structural properties of tetherin that provide the basis to physically retain HIV-1 by bridging plasma and virion membranes after completion of budding.
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Dates et versions

hal-01138510 , version 1 (02-04-2015)

Identifiants

  • HAL Id : hal-01138510 , version 1
  • PUBMED : 22524178

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Winfried Weissenhorn, Nolwenn Miguet, Nick Aschman, Patricia Renesto, Yoshiko Usami, et al.. Structural basis of tetherin function.. Current HIV Research, 2012, 10 (4), pp.298-306. ⟨hal-01138510⟩
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