New challenges in modern vaccinology - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue BMC Immunology Année : 2015

New challenges in modern vaccinology

Résumé

Vaccination has been a major advance for health care, allowing eradication or reduction of incidence and mortality of various infectious diseases. However, there are major pathogens, such as Human Immunodeficiency Virus (HIV) or the causative agent of malaria, for which classical vaccination approaches have failed, therefore requiring new vaccination strategies. The development of new vaccine strategies relies on the ability to identify the challenges posed by these pathogens. Understanding the pathogenesis and correlates of protection for these diseases, our ability to accurately direct immune responses and to vaccinate specific populations are such examples of these roadblocks. In this respect, the use of a robust, cost-effective and predictive animal model that recapitulates features of both human infection and vaccination is currently a much-needed tool. We discuss here the major limitations faced by modern vaccinology and notably, the development of humanized mice for assessing the immune system, along with their potential as vaccine models.
Fichier principal
Vignette du fichier
Centlivre_2015_New_challenges_in.pdf (361.67 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01149658 , version 1 (07-05-2015)

Licence

Paternité

Identifiants

Citer

Mireille Centlivre, Béhazine Combadière. New challenges in modern vaccinology. BMC Immunology, 2015, 16 (1), pp.18. ⟨10.1186/s12865-015-0075-2⟩. ⟨hal-01149658⟩
140 Consultations
140 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More