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Article Dans Une Revue Bioinformatics Année : 2014

Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network.

Résumé

Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network.

Dates et versions

hal-01150065 , version 1 (08-05-2015)

Identifiants

Citer

Nicolas Jung, Frédéric Bertrand, Seiamak Bahram, Laurent Vallat, Myriam Maumy-Bertrand. Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network.. Bioinformatics, 2014, 3 (4), pp.571-3. ⟨10.1093/bioinformatics/btt705⟩. ⟨hal-01150065⟩
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