Antipolar and Anticlinic Mesophase Order in Chromatin Induced by Nucleosome Polarity and Chirality Correlations - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Physical Review Letters Année : 2015

Antipolar and Anticlinic Mesophase Order in Chromatin Induced by Nucleosome Polarity and Chirality Correlations

Renata Garces
  • Fonction : Auteur
  • PersonId : 938263
Vladimir Lorman
  • Fonction : Auteur
  • PersonId : 888549

Résumé

Contrary to the usual “rigid supermolecular assembly” paradigm of chromatin structure, we propose to analyze its eventual ordered state in terms of symmetry properties of individual nucleosomes that give rise to mesophase order parameters, like in many other soft-matter systems. Basing our approach on the Landau–de Gennes phenomenology, we describe the mesoscale order in chromatin by antipolar and anticlinic correlations of chiral individual nucleosomes. This approach leads to a unifying physical picture of a whole series of soft locally ordered states with different apparent structures, including the recently observed heteromorphic chromatin, stemming from the antipolar arrangement of nucleosomes complemented by their chiral twisting. Properties of these states under an external force field can reconcile apparently contradictory results of single-molecule experiments.
Fichier principal
Vignette du fichier
Garces_tri_VL3.pdf (1.17 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01163612 , version 1 (03-06-2021)

Licence

Paternité

Identifiants

Citer

Renata Garces, R. Podgornik, Vladimir Lorman. Antipolar and Anticlinic Mesophase Order in Chromatin Induced by Nucleosome Polarity and Chirality Correlations. Physical Review Letters, 2015, 114 (23), pp.238102. ⟨10.1103/PhysRevLett.114.238102⟩. ⟨hal-01163612⟩
53 Consultations
33 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More