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Communication Dans Un Congrès Année : 2015

HUXLEY-SIMMONS MODEL REVISITED

Résumé

Muscle contraction is a largely mechanical process taking place at the sub-cellular level. While being an intrinsically active system the contractile apparatus also displays some intriguing passive mechanical properties including negative stiffness and a fundamental nonequivalence of isometric and isotonic loading protocols. We reveal the origin of this unusual behavior by analyzing a conceptual model which represents a delicate generalization of the Huxley-Simmons model. Our analytically explicit study sheds light on the crucial role of long-range interactions in this system. The model can be easily adapted to a wide class of biological phenomena involving cooperative switching mediated by effective backbones, from muscle power-stroke to gating, binding and folding.
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Dates et versions

hal-01180003 , version 1 (23-07-2015)

Identifiants

  • HAL Id : hal-01180003 , version 1

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Matthieu Caruel, Lev Truskinovsky. HUXLEY-SIMMONS MODEL REVISITED. 4th International Conference on Computational and Mathematical Biomedical Engineering - CMBE2015, Jun 2015, Paris, France. ⟨hal-01180003⟩
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