Identification of odorant-receptor interactions by global mapping of the human odorome - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2014

Identification of odorant-receptor interactions by global mapping of the human odorome

Résumé

The human olfactory system recognizes a broad spectrum of odorants using approximately 400 different olfactory receptors ( hORs). Although significant improvements of heterologous expression systems used to study interactions between ORs and odorant molecules have been made, screening the olfactory repertoire of hORs remains a tremendous challenge. We therefore developed a chemical systems level approach based on protein-protein association network to investigate novel hOR-odorant relationships. Using this new approach, we proposed and validated new bioactivities for odorant molecules and OR2W1, OR51E1 and OR5P3. As it remains largely unknown how human perception of odorants influence or prevent diseases, we also developed an odorant-protein matrix to explore global relationships between chemicals, biological targets and disease susceptibilities. We successfully experimentally demonstrated interactions between odorants and the cannabinoid receptor 1 (CB1) and the peroxisome proliferator-activated receptor gamma ( PPAR gamma). Overall, these results illustrate the potential of integrative systems chemical biology to explore the impact of odorant molecules on human health, i.e. human odorome.
Fichier principal
Vignette du fichier
2014_Audouze_Plosone_{53BFE671-DE5D-415E-A454-37F90CA36AB7}.pdf (1.43 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01185026 , version 1 (18-08-2015)

Identifiants

Citer

Karine Audouze, Anne Tromelin, Anne-Marie Le Bon, Christine Belloir, Rasmus Koefoed Petersen, et al.. Identification of odorant-receptor interactions by global mapping of the human odorome. PLoS ONE, 2014, 9 (4), ⟨10.1371/journal.pone.0093037⟩. ⟨hal-01185026⟩
93 Consultations
104 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More