Diversity in Synthesis of N-Heterocycles from Simple Propargylic Alcohols - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue SYNLETT Année : 2015

Diversity in Synthesis of N-Heterocycles from Simple Propargylic Alcohols

Résumé

In this account, we summarize our recent work on the preparation of various N-heterocycles, starting from propargylic alcohols. Our aim was to develop versatile and selective one-pot procedures that would permit the synthesis of large collections of heterocycles, such as di- or tri-substituted isoxazolines and isoxazoles, cis-aziridines, and pyrimidines, by fine changes in the reaction conditions. When needed, mechanistic studies have been performed by combining experimental work with density functional theory calculations. 1 Introduction 2 Synthesis of Disubstituted Isoxazolines 3 Synthesis of Disubstituted Isoxazoles 4 Synthesis of cis-Acylaziridines 5 Trisubstituted Isoxazolines and Isoxazoles 6 β-Enaminones and Pyrimidines 7 Conclusioni

Domaines

Chimie organique
Fichier non déposé

Dates et versions

hal-01218485 , version 1 (21-10-2015)

Identifiants

Citer

Eric Gayon, Hélène Gérard, Emmanuel Vrancken, Jean-Marc Campagne. Diversity in Synthesis of N-Heterocycles from Simple Propargylic Alcohols. SYNLETT, 2015, 26 (17), pp.2336-2350. ⟨10.1055/s-0034-1378804⟩. ⟨hal-01218485⟩
324 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More