Towards understanding the interplay between intraocular pressure and blood pressure: a mathematical model.
Résumé
Elevated intraocular pressure (IOP), clinically referred to as ocular hypertension (OHT), is a recognized risk factor for irreversible vision loss. Moreover, clinical studies showed that alterations in blood pressure (BP) are often associated with many ocular diseases. Thus, the combined effect of IOP and BP should be taken into account when assessing disease risks and evaluating the outcomes of different treatments on a specific patient. For example, the outcomes of IOP-lowering medications used for the treatment of OHT are observed to vary significantly among individuals, even though the factors influencing such variability are not yet fully understood. Here we propose a mathematical model to theoretically investigate the relationship between IOP and BP, with the aim of evaluating their potential impact on the individual response to IOP-lowering medications.