Emergence of cytotoxic resistance in cancer cell populations - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Communication Dans Un Congrès Année : 2015

Emergence of cytotoxic resistance in cancer cell populations

Résumé

We formulate an individual-based model and an integro-differential model of phenotypic evolution, under cytotoxic drugs, in a cancer cell population structured by the expression levels of survival-potential and proliferation-potential. We apply these models to a recently studied experimental system. Our results suggest that mechanisms based on fundamental laws of biology can reversibly push an actively-proliferating, and drug-sensitive, cell population to transition into a weakly-proliferative and drug-tolerant state, which will eventually facilitate the emergence of more potent, proliferating and drug-tolerant cells.
Fichier principal
Vignette du fichier
itmconf_mod2015_00009.pdf (86.43 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-01249235 , version 1 (04-01-2016)

Identifiants

Citer

Tommaso Lorenzi, Rebecca H. Chisholm, Alexander Lorz, Annette K Larsen, Luís Almeida, et al.. Emergence of cytotoxic resistance in cancer cell populations: From individual-level mechanisms to population-level consequences. Workshop on Multiscale and Hybrid Modelling in Cell and Cell Population Biology, V. Volpert and J. Clairambault, Mar 2015, Paris, France. ⟨10.1051/itmconf/20150500009⟩. ⟨hal-01249235⟩
383 Consultations
171 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More