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Article Dans Une Revue (Article De Synthèse) Current Opinion in Chemical Biology Année : 2014

CAZyme discovery and design for sweet dreams

Résumé

Development of synthetic routes to complex carbohydrates and glyco-conjugates is often hampered by the lack of enzymes with requisite properties or specificities. Indeed, assembly or degradation of carbohydrates requires carbohydrate-active enzymes (CAZymes) able to act on a vast range of glycosidic monomers, oligomers or polymers in a regio-specific or stereo-specific manner in order to produce the desired structure. Sequence-based analyses allow finding the most original enzymes. Novel screening methods have emerged that enable a more efficient exploitation of the CAZyme diversity found in the microbial world or generated by protein engineering. Computational biology methods also play a prominent role in the success of CAZyme design. Such progress allows circumventing current limitations of carbohydrate synthesis and opens new opportunities related to the synthetic biology field.
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Dates et versions

hal-01268759 , version 1 (04-02-2016)

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Isabelle André, Gabrielle Veronese, Sophie Barbe, Claire Moulis, Magali Remaud Simeon. CAZyme discovery and design for sweet dreams. Current Opinion in Chemical Biology, 2014, 19, pp.17-24. ⟨10.1016/j.cbpa.2013.11.014⟩. ⟨hal-01268759⟩
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