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Article Dans Une Revue Nucleic Acids Research Année : 2015

CellWhere: graphical display of interaction networks organized on subcellular localizations

Résumé

Given a query list of genes or proteins, CellWhere produces an interactive graphical display that mimics the structure of a cell, showing the local interaction network organized into subcellular locations. This user-friendly tool helps in the formulation of mechanistic hypotheses by enabling the experimental biologist to explore simultaneously two elements of functional context: (i) protein subcellular localization and (ii) protein–protein interactions or gene functional associations. Subcellular localization terms are obtained from public sources (the Gene Ontology and UniProt—together containing several thousand such terms) then mapped onto a smaller number of CellWhere localizations. These localizations include all major cell compartments, but the user may modify the mapping as desired. Protein–protein interaction listings, and their associated evidence strength scores, are obtained from the Mentha interactome server, or power-users may upload a pre-made network produced using some other interactomics tool. The Cytoscape.js JavaScript library is used in producing the graphical display. Importantly, for a protein that has been observed at multiple subcellular locations, users may prioritize the visual display of locations that are of special relevance to their research domain. CellWhere is at http://cellwhere-myology.rhcloud.com.
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Dates et versions

hal-01277971 , version 1 (23-02-2016)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Lu Zhu, Apostolos Malatras, Matthew Thorley, Idonnya Aghoghogbe, Arvind Mer, et al.. CellWhere: graphical display of interaction networks organized on subcellular localizations. Nucleic Acids Research, 2015, 43 (W1), pp.W571-W575. ⟨10.1093/nar/gkv354⟩. ⟨hal-01277971⟩
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