Quantitative Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides as a Versatile Tool to Tune Their Properties - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue ACS Macro Letters Année : 2015

Quantitative Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides as a Versatile Tool to Tune Their Properties

Résumé

Tuning the lower critical solution temperature (LCST) of temperature-responsive recombinant elastin-like polypeptides has usually been achieved by designing different protein sequences, in terms of amino acid composition and length, implying tedious molecular cloning steps. In the present work, we have explored the chemoselective alkylation of methionine as an easy means to modify elastin repeat side chains and easily modulate the LCST of the polypeptides. Such a versatile synthetic method shall practically be exploited to modulate any properties of recombinant polymers.

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hal-01361956 , version 1 (07-09-2016)

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Jessica R. Kramer, Rosine Petitdemange, Laure Bataille, Katell Bathany, Anne-Laure Wirotius, et al.. Quantitative Side-Chain Modifications of Methionine-Containing Elastin-Like Polypeptides as a Versatile Tool to Tune Their Properties . ACS Macro Letters, 2015, 4 (11), pp.1283-1286. ⟨10.1021/acsmacrolett.5b00651⟩. ⟨hal-01361956⟩

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