Metastatic hepatocellular carcinoma: when surgery and successive palliative treatments lead to remission. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Clinics and Research in Hepatology and Gastroenterology Année : 2014

Metastatic hepatocellular carcinoma: when surgery and successive palliative treatments lead to remission.

Charlène Brochard
  • Fonction : Auteur
Antoine Hamy
  • Fonction : Auteur
  • PersonId : 992105
Sophie Michalak
  • Fonction : Auteur
  • PersonId : 991973
Nathalie Nebout
  • Fonction : Auteur
François-Xavier Caroli-Bosc
  • Fonction : Auteur
  • PersonId : 992104
Frédéric Oberti
  • Fonction : Auteur
  • PersonId : 991974
Jérôme Boursier
  • Fonction : Auteur
  • PersonId : 916784

Résumé

Hepatocellular carcinoma (HCC) is the third leading cause of death by cancer worldwide. The prognosis of patients with metastatic HCC remains limited, with an expected median survival lower than 50% at 1 year. Here, we report the case of a 63-year-old man who suffered from a small HCC in the liver and a large unique metastasis in the right adrenal gland. A surgical resection of both lesions was performed. Seven months later, HCC recurred with an isolated right renal metastatic lymphadenopathy and a high alpha-fetoprotein level. HCC was brought under control by sorafenib; the alpha-fetoprotein level was greatly reduced but remained moderately elevated and stable over 2 years after the onset of chemotherapy. Additional external radiotherapy on the metastatic lymphadenopathy led to a normalization of the alpha-fetoprotein level and discontinuation of sorafenib treatment. One year after the end of radiotherapy, a second isolated metastasis occurred in the right lung. This tumor was surgically removed. Twenty-one months after this second surgical procedure, i.e., more than 5.5 years after the initial diagnosis of metastatic HCC, the patient was asymptomatic and tumor free.

Fichier non déposé

Dates et versions

hal-01390669 , version 1 (02-11-2016)

Identifiants

Citer

Charlène Brochard, Antoine Hamy, Sophie Michalak, Christophe Aubé, Jean Picquet, et al.. Metastatic hepatocellular carcinoma: when surgery and successive palliative treatments lead to remission.. Clinics and Research in Hepatology and Gastroenterology, 2014, 38, pp.e19-22. ⟨10.1016/j.clinre.2013.02.006⟩. ⟨hal-01390669⟩
28 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More