Chiral additive induced self-disproportionation of enantiomers under MPLC conditions: preparation of enantiomerically pure samples of 1-(aryl)ethylamines from racemates - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Tetrahedron: Asymmetry Année : 2016

Chiral additive induced self-disproportionation of enantiomers under MPLC conditions: preparation of enantiomerically pure samples of 1-(aryl)ethylamines from racemates

Résumé

Mixtures of enantiomerically pure (S)-N-formyl-1-phenylethyamine and various racemic N-formyl-1-arylethylamine derivatives, when submitted to achiral medium pressure liquid chromatography, afforded elution profiles in which the enantiomers of N-formyl-1-arylethylamines standout as separate peaks and can be isolated. In all of the investigated N-formyl-1-arylethylamine substrates, the virtually enantiomerically pure (S)-enantiomer eluted as a less polar fraction and subsequently, the (R)-enriched enantiomer mixtures were eluted in the more polar fractions.

Domaines

Chimie
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Dates et versions

hal-01442594 , version 1 (20-01-2017)

Identifiants

Citer

Mitsuhiro Goto, Kaori Tateishi, Kenki Ebine, Vadim A. Soloshonok, Christian Roussel, et al.. Chiral additive induced self-disproportionation of enantiomers under MPLC conditions: preparation of enantiomerically pure samples of 1-(aryl)ethylamines from racemates. Tetrahedron: Asymmetry, 2016, 27 (7-8), pp.317 - 321. ⟨10.1016/j.tetasy.2016.03.004⟩. ⟨hal-01442594⟩
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