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Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2010

Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization

Résumé

Chemoenzymatic dynamic kinetic resolution (DKR) of amines involving sulfanyl radical-induced racemization happened to be the very first switchable DKR process allowing the synthesis of either (R)- or (S)-amides, in good yield and high enantiomeric excess, depending on the nature of the enzyme; the different steps of the development of (S)-selective DKR are discussed.

Domaines

Chimie

Dates et versions

hal-01460202 , version 1 (07-02-2017)

Identifiants

Citer

Lahssen El Blidi, Nicolas Vanthuyne, Didier Siri, Stéphane Gastaldi, Michèle P. Bertrand, et al.. Switching from (R)- to (S)-selective chemoenzymatic DKR of amines involving sulfanyl radical-mediated racemization. Organic & Biomolecular Chemistry, 2010, 8 (18), pp.4165--4168. ⟨10.1039/c0ob00054j⟩. ⟨hal-01460202⟩
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