Pyridine-Based Heterocycles. Synthesis of New Pyrido [4 ',3 ':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
Résumé
The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4 ',3 ': 4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
Domaines
Chimie organique
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