Pyridine-Based Heterocycles. Synthesis of New Pyrido [4 ',3 ':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Molecules Année : 2010

Pyridine-Based Heterocycles. Synthesis of New Pyrido [4 ',3 ':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

Résumé

The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4 ',3 ': 4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.

Domaines

Chimie organique
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Dates et versions

hal-01460203 , version 1 (21-06-2023)

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Hussein El-Kashef, Abdel-Rahman Farghaly, Ahmed Al-Hazmi, Thierry Terme, Patrice Vanelle. Pyridine-Based Heterocycles. Synthesis of New Pyrido [4 ',3 ':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles. Molecules, 2010, 15 (4), pp.2651--2666. ⟨10.3390/molecules15042651⟩. ⟨hal-01460203⟩
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