Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation. - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Année : 2005

Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation.

Résumé

Acquisition and performance of instrumental actions are assumed to require both action-outcome and stimulus-response (S-R) habit processes. Over the course of extended training, control over instrumental performance shifts from goal-directed action-outcome associations to S-R associations that progressively gain domination over behavior. Lesions of the lateral part of the dorsal striatum disrupt this process, and rats with lesions to the lateral striatum showed selective sensitivity to devaluation of the instrumental outcome (Yin et al., 2004), indicating that this area is necessary for habit formation. The present experiment further explored the basis of this dysfunction by examining the ability of rats subjected to bilateral 6-hydroxydopamine lesions of the nigrostriatal dopaminergic pathway to develop behavioral autonomy with overtraining. Rats were given extended training on two cued instrumental tasks associating a stimulus (a tone or a light) with an instrumental action (lever press or chain pull) and a food reward (pellets or sucrose). Both tasks were run daily in separate sessions. Overtraining was followed by a test of goal sensitivity by satiety-specific devaluation of the reward. In control animals, one action (lever press) was insensitive to reward devaluation, indicating that it became a habit, whereas the second action (chain pull) was still sensitive to goal devaluation. This result provides evidence that the development of habit learning may depend on the characteristics of the response. In dopamine-depleted rats, lever press and chain pull remained sensitive to reward devaluation, evidencing a role of striatal dopamine transmission in habit formation.

Dates et versions

hal-01467528 , version 1 (14-02-2017)

Identifiants

Citer

Alexis Faure, Ulrike Haberland, Françoise Condé, Nicole El Massioui. Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation.. Journal of Neuroscience, 2005, 25 (11), pp.2771-80. ⟨10.1523/JNEUROSCI.3894-04.2005⟩. ⟨hal-01467528⟩
144 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More