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Article Dans Une Revue PLoS ONE Année : 2013

Doublecortin Knockout Mice Show Normal Hippocampal-Dependent Memory Despite CA3 Lamination Defects

Johanne Germain
  • Fonction : Auteur
Elodie Bruel-Jungerman
  • Fonction : Auteur
Gael Grannec
  • Fonction : Auteur
Cecile Denis
  • Fonction : Auteur
Gabriel Lepousez
Fiona Francis
Marika Nosten-Bertrand
  • Fonction : Auteur

Résumé

Mutations in the human X-linked doublecortin gene (DCX) cause major neocortical disorganization associated with severe intellectual disability and intractable epilepsy. Although Dcx knockout (KO) mice exhibit normal isocortical development and architecture, they show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 region. Dcx-KO mice also exhibit interneuron abnormalities. As well as the interest of testing their general neurocognitive profile, Dcx-KO mice also provide a relatively unique model to assess the effects of a disorganized CA3 region on learning and memory. Based on its prominent anatomical and physiological features, the CA3 region is believed to contribute to rapid encoding of novel information, formation and storage of arbitrary associations, novelty detection, and short-term memory. We report here that Dcx-KO adult males exhibit remarkably preserved hippocampal-and CA3-dependant cognitive processes using a large battery of classical hippocampus related tests such as the Barnes maze, contextual fear conditioning, paired associate learning and object recognition. In addition, we show that hippocampal adult neurogenesis, in terms of proliferation, survival and differentiation of granule cells, is also remarkably preserved in Dcx-KO mice. In contrast, following social deprivation, Dcx-KO mice exhibit impaired social interaction and reduced aggressive behaviors. In addition, Dcx-KO mice show reduced behavioral lateralization. The Dcx-KO model thus reinforces the association of neuropsychiatric behavioral impairments with mouse models of intellectual disability.

Dates et versions

hal-01542332 , version 1 (19-06-2017)

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Citer

Johanne Germain, Elodie Bruel-Jungerman, Gael Grannec, Cecile Denis, Gabriel Lepousez, et al.. Doublecortin Knockout Mice Show Normal Hippocampal-Dependent Memory Despite CA3 Lamination Defects. PLoS ONE, 2013, 8 (9), pp.e74992. ⟨10.1371/journal.pone.0074992⟩. ⟨hal-01542332⟩
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