Expression and modification proteomics during skeletal muscle ageing - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Biogerontology Année : 2013

Expression and modification proteomics during skeletal muscle ageing

Marine Gueugneau
Stephanie Duguez
  • Fonction : Auteur
Gillian Butler-Browne
Daniel Bechet

Résumé

Skeletal muscle ageing is characterized by a progressive and dramatic loss of muscle mass and strength leading to decreased muscular function resulting in muscle weakness which is often referred to as sarcopenia. Following the standardisation of ``omics'' approaches to study the genome (genomics) and the transcriptome (transcriptomics), the study of the proteins encoded by the genome, referred to as proteomics, is a tremendous challenge. Unlike the genome, the proteome varies in response to many physiological or pathological factors. In addition, the proteome is orders of magnitude more complex than the transcriptome due to post-translational modifications, protein oxidation and limited protein degradation. Proteomic studies, including the analysis of protein abundance as well as post-translational modified proteins have been shown to provide valuable information to unravel the key molecular pathways implicated in complex biological processes, such as tissue and organ ageing. In this article, we will describe proteomic approaches for the analysis of protein abundance as well as the specific protein targets for oxidative damage upon oxidative stress and/or during skeletal muscle ageing.

Dates et versions

hal-01543981 , version 1 (21-06-2017)

Identifiants

Citer

Martin A. Baraibar, Marine Gueugneau, Stephanie Duguez, Gillian Butler-Browne, Daniel Bechet, et al.. Expression and modification proteomics during skeletal muscle ageing. Biogerontology, 2013, 14 (3, SI), pp.339-352. ⟨10.1007/s10522-013-9426-7⟩. ⟨hal-01543981⟩
38 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More