Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Journal of Cerebral Blood Flow and Metabolism Année : 2017

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

C. Daniel de Magalhaes Filho
  • Fonction : Auteur
Laurent Kappeler
  • Fonction : Auteur
Joelle Dupont
Julien Solinc
Sonia Villapol
  • Fonction : Auteur
Cecile Denis
  • Fonction : Auteur
Marika Nosten-Bertrand
  • Fonction : Auteur
Jean-Marie Billard
Annick Blaise
  • Fonction : Auteur
Bruno Giros
Christiane Charriaut-Marlangue
  • Fonction : Auteur
Saba Aid
Yves Le Bouc
  • Fonction : Auteur
Martin Holzenberger
  • Fonction : Auteur

Résumé

Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging and age-related diseases. Insulin-like growth factor signaling also impacts on neurogenesis, neuronal survival and structural plasticity. Recent reports demonstrated that diminished insulin-like growth factor signaling confers increased stress resistance in brain and other tissues. To better understand the role of neuronal insulin-like growth factor signaling in neuroprotection, we inactivated insulin-like growth factor type-1-receptor in forebrain neurons using conditional Cre-LoxP-mediated gene targeting. We found that brain structure and function, including memory performance, were preserved in insulin-like growth factor receptor mutants, and that certain characteristics improved, notably synaptic transmission in hippocampal neurons. To reveal stress-related roles of insulin-like growth factor signaling, we challenged the brain using a stroke-like insult. Importantly, when charged with hypoxia-ischemia, mutant brains were broadly protected from cell damage, neuroinflammation and cerebral edema. We also found that in mice with insulin-like growth factor receptor knockout specifically in forebrain neurons, a substantial systemic upregulation of growth hormone and insulin-like growth factor-I occurred, which was associated with significant somatic overgrowth. Collectively, we found strong evidence that blocking neuronal insulin-like growth factor signaling increases peripheral somatotropic tone and simultaneously protects the brain against hypoxic-ischemic injury, findings that may contribute to developing new therapeutic concepts preventing the disabling consequences of stroke.

Dates et versions

hal-01544137 , version 1 (21-06-2017)

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Citer

C. Daniel de Magalhaes Filho, Laurent Kappeler, Joelle Dupont, Julien Solinc, Sonia Villapol, et al.. Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin. Journal of Cerebral Blood Flow and Metabolism, 2017, 37 (2), pp.396-412. ⟨10.1177/0271678X15626718⟩. ⟨hal-01544137⟩
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