Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Neurobiology of Aging Année : 2014

Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate

Cédric Annweiler
Robert Bartha
  • Fonction : Auteur
Olivier Beauchet

Résumé

The currently available drugs for treatment of Alzheimer's disease are symptomatic and only temporarily slow down the natural history of the disease process. Recently, its has been proposed that the combination of memantine with vitamin D, a neurosteroid hormone, may prevent amyloid-beta and glutamate neurotoxicity. Here, our purpose was to examine the potential protective effects of memantine and vitamin D against amyloid-beta peptide and glutamate toxicity in cortical neuronal cultures. We provide the first evidence that cortical axons degenerate less after exposure to amyloid-beta peptide or glutamate in microfluidic neuronal cultures enriched with memantine plus vitamin D compared to control medium and cultures enriched with only memantine or only vitamin D. The reported synergistic neuroprotective effect of memantine plus vitamin D-the combination originating an effect stronger than the sum-corroborate previous clinical finding that Alzheimer's disease patients using this drug combination have improved cognition. This finding reinforces the pharmacological potential of a new drug combining memantine plus vitamin D for the treatment or the prevention of Alzheimer's disease.
Fichier non déposé

Dates et versions

hal-01544168 , version 1 (21-06-2017)

Identifiants

Citer

Cédric Annweiler, Bernard Brugg, Jean-Michel Peyrin, Robert Bartha, Olivier Beauchet. Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate. Neurobiology of Aging, 2014, 35 (2), pp.331-335. ⟨10.1016/j.neurobiolaging.2013.07.029⟩. ⟨hal-01544168⟩
60 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More