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Article Dans Une Revue PLoS ONE Année : 2012

Impaired Adaptive Response to Mechanical Overloading in Dystrophic Skeletal Muscle

Pierre Joanne
Christophe Hourde
  • Fonction : Auteur
Julien Ochala
  • Fonction : Auteur
Yvain Cauderan
  • Fonction : Auteur
Fadia Medja
  • Fonction : Auteur
Alban Vignaud
  • Fonction : Auteur
Etienne Mouisel
  • Fonction : Auteur
Wahiba Hadj-Said
  • Fonction : Auteur
Ludovic Arandel
Luis Garcia
  • Fonction : Auteur
Aurelie Goyenvalle
Remi Mounier
  • Fonction : Auteur
Daria Zibroba
  • Fonction : Auteur
Kei Sakamato
  • Fonction : Auteur
Gillian Butler-Browne
Onnik Agbulut
Arnaud Ferry

Résumé

Dystrophin contributes to force transmission and has a protein-scaffolding role for a variety of signaling complexes in skeletal muscle. In the present study, we tested the hypothesis that the muscle adaptive response following mechanical overloading (ML) would be decreased in MDX dystrophic muscle lacking dystrophin. We found that the gains in muscle maximal force production and fatigue resistance in response to ML were both reduced in MDX mice as compared to healthy mice. MDX muscle also exhibited decreased cellular and molecular muscle remodeling (hypertrophy and promotion of slower/oxidative fiber type) in response to ML, and altered intracellular signalings involved in muscle growth and maintenance (mTOR, myostatin, follistatin, AMPK alpha 1, REDD1, atrogin-1, Bnip3). Moreover, dystrophin rescue via exon skipping restored the adaptive response to ML. Therefore our results demonstrate that the adaptive response in response to ML is impaired in dystrophic MDX muscle, most likely because of the dystrophin crucial role.

Dates et versions

hal-01545458 , version 1 (22-06-2017)

Identifiants

Citer

Pierre Joanne, Christophe Hourde, Julien Ochala, Yvain Cauderan, Fadia Medja, et al.. Impaired Adaptive Response to Mechanical Overloading in Dystrophic Skeletal Muscle. PLoS ONE, 2012, 7 (4), pp.e35346. ⟨10.1371/journal.pone.0035346⟩. ⟨hal-01545458⟩
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