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Communication Dans Un Congrès Année : 2016

Genome-Wide Alterations of the DNA Replication Program during Tumor Progression

A. Arneodo
Françoise Argoul
O. Hyrien
B. Audit

Résumé

Oncogenic stress is a major driving force in the early stages of cancer development. Recent experimental findings reveal that, in precancerous lesions and cancers, activated oncogenes may induce stalling and dissociation of DNA replication forks resulting in DNA damage. Replication timing is emerging as an important epigenetic feature that recapitulates several genomic, epigenetic and functional specificities of even closely related cell types. There is increasing evidence that chromosome rearrangements, the hallmark of many cancer genomes, are intimately associated with the DNA replication program and that epigenetic replication timing changes often precede chromosomic rearrangements. The recent development of a novel methodology to map replication fork polarity using deep sequencing of Okazaki fragments has provided new and complementary genome-wide replication profiling data. We review the results of a wavelet-based multi-scale analysis of genomic and epigenetic data including replication profiles alon...
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Dates et versions

hal-01556059 , version 1 (04-07-2017)

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Citer

A. Arneodo, A. Goldar, Françoise Argoul, O. Hyrien, B. Audit. Genome-Wide Alterations of the DNA Replication Program during Tumor Progression. Physics of cancer: Interdisciplinary problems and clinical applications (PC’16), Mar 2016, Tomsk, Russia. pp.020002, ⟨10.1063/1.4960221⟩. ⟨hal-01556059⟩
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