Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue PLoS Computational Biology Année : 2017

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

Résumé

The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a " public " repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleotides is downregulated, producing a limited diversity subset. By statistically analyzing deep sequencing T-cell repertoire data from twins, unrelated individuals of various ages, and cord blood, we show that T-cell clones generated before birth persist and maintain high abundances in adult organisms for decades, slowly decaying with age. Our results suggest that large, low-diversity public clones are created during pre-natal life, and survive over long periods, providing the basis of the public repertoire.
Fichier principal
Vignette du fichier
journal.pcbi.1005572.pdf (4.46 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01579464 , version 1 (31-08-2017)

Licence

Paternité

Identifiants

Citer

Mikhail V. Pogorelyy, Yuval Elhanati, Quentin Marcou, Anastasiia L. Sycheva, Ekaterina A. Komech, et al.. Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires. PLoS Computational Biology, 2017, 13 (7), pp.e1005572. ⟨10.1371/journal.pcbi.1005572⟩. ⟨hal-01579464⟩
383 Consultations
123 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More