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Article Dans Une Revue Nanomedicine: Nanotechnology, Biology and Medicine Année : 2017

Magnetically-induced elimination of Staphylococcus aureus by magnetotactic bacteria under a swing magnetic field

Changyou Chen
  • Fonction : Auteur
Pingping Wang
  • Fonction : Auteur
Long-Fei Wu
Tao Song
  • Fonction : Auteur

Résumé

This study aims to explore a therapeutic tool that kills pathogens by using mechanical force other than temperature. We fabricated a device that generates a swing magnetic field (sMF) with low-heat production and then evaluated the killing effect of magnetotactic bacteria MO-1 on Staphylococcus aureus (S. aureus) under the sMF. S. aureus was only killed under the sMF when attached to MO-1 cells. The killing efficiency increased with increasing attachment ratio of MO-1 cells to S. aureus. Treatment with antibody-coated MO-1 cells under the sMF improved the healing of S. aureus-infected wound. The theoretical analysis demonstrated that MO-1 cells generated a mechanical force of approximately 8 kPa under the sMF, thereby exerting on S. aureus and inducing cell death. The proposed platform, which uses magnetotactic bacteria under the sMF to generate mechanical force, provides a basis for development of therapeutic tools to treat infectious diseases. (C) 2016 Elsevier Inc. All rights reserved.
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Dates et versions

hal-01640031 , version 1 (20-11-2017)

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Citer

Changyou Chen, Linjie Chen, Pingping Wang, Long-Fei Wu, Tao Song. Magnetically-induced elimination of Staphylococcus aureus by magnetotactic bacteria under a swing magnetic field. Nanomedicine: Nanotechnology, Biology and Medicine, 2017, 13 (2), pp.363--370. ⟨10.1016/j.nano.2016.08.021⟩. ⟨hal-01640031⟩
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