Tsavoenones A-C Unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Organic & Biomolecular Chemistry Année : 2018

Tsavoenones A-C Unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense

Résumé

New racemic dispiranic polyketides, tsavoenones A (1), B (2) and C (3), having a novel 1,7-dioxadispiro[4.0.4.4]tetradecane scaffold were isolated from the foliose lichen Parmotrema tsavoense. These compounds were structurally elucidated by extensive NMR analyses, comparison between experimental and theoretical 13C NMR data and X-ray crystallography. A putative biosynthetic scenario for the formation of 1-3 from parmosidone D, a meta-depsidone previously isolated from the same lichen material, was proposed. Tested for its cytotoxicity, 1 displayed a moderate activity against human myelogenous leukemia K562 cell line with an IC50 value of 66 μg mL-1. © 2018 The Royal Society of Chemistry.

Domaines

Chimie
Fichier non déposé

Dates et versions

hal-01875216 , version 1 (17-09-2018)

Identifiants

Citer

T.-H. Duong, M.A. Beniddir, G. Genta-Jouve, T. Aree, M. Chollet-Krugler, et al.. Tsavoenones A-C Unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense. Organic & Biomolecular Chemistry, 2018, 16 (32), pp.5913-5919. ⟨10.1039/c8ob01280f⟩. ⟨hal-01875216⟩
15 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More