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Article Dans Une Revue Nano Letters Année : 2016

B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy

Résumé

Adoptive cell therapy represents a promising approach for several chronic diseases. This study describes an innovative strategy for biofunctionalization of nanoparticles, allowing the generation of synthetic particulate antigens (SPAg). SPAg activate polyclonal B cells and vectorize noncognate proteins into their endosomes, generating highly efficient stimulators for ex vivo expansion of antigen-specific CD4+ T cells. This method also allows harnessing the ability of B cells to polarize CD4+ T cells into effectors or regulators.
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Dates et versions

hal-01909010 , version 1 (30-10-2018)

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Antoine Sicard, Alice Koenig, Stéphanie Graff-Dubois, Sébastien Dussurgey, Angéline Rouers, et al.. B Cells Loaded with Synthetic Particulate Antigens: A Versatile Platform To Generate Antigen-Specific Helper T Cells for Cell Therapy. Nano Letters, 2016, 16 (1), pp.297-308. ⟨10.1021/acs.nanolett.5b03801⟩. ⟨hal-01909010⟩
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