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Article Dans Une Revue Journal of Alzheimer's Disease Année : 2018

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

1 CHU Pitié-Salpêtrière [AP-HP]
2 Università degli Studi di Roma Tor Vergata [Roma] = University of Rome Tor Vergata
3 UNIROMA - Università degli Studi di Roma "La Sapienza" = Sapienza University [Rome]
4 University of Pisa - Università di Pisa
5 ICM - Institut du Cerveau = Paris Brain Institute
6 GRC 21 - APM - Groupe de recherche clinique Alzheimer Precision Medicine
7 IM2A - Institut de la Mémoire et de la Maladie d'Alzheimer [CHU Pitié-Salpétriêre]
8 Cedars-Sinai Medical Center
9 Discipline of Psychiatry [Dublin]
10 SU - Sorbonne Université
11 Azienda Ospedaliera Universitaria Senese
12 ARAMIS - Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris]
13 UZH - Universität Zürich [Zürich] = University of Zurich
14 Centre des Maladies Cognitives et Comportementales [Paris]
15 LIB - Laboratoire d'Imagerie Biomédicale [Paris]
16 WMIC - Wolfson Molecular Imaging Centre
17 Functional Neuromodulation
18 CENIR - Plateforme de neuroimagerie CENIR = Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris]
19 Institut de la Vision
20 Edin. - University of Edinburgh
21 UNISI - Università degli Studi di Siena = University of Siena
22 Indiana State University
23 NeuroVision Imaging
24 Medisys - MedisysResearch Lab
25 EUSTM - European Society for Translational Medicine
26 IRCCS San Raffaele Pisana - Istituto di Ricovero e Cura a Carattere Scientifico
Harald Hampel
Karl Herholz
  • Fonction : Auteur
  • PersonId : 889961
Foudil Lamari
Jean Lorenceau
  • Fonction : Auteur
  • PersonId : 837588
Christian Néri
Nicolas Villain
Simone Lista

Résumé

The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an “omics”-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical, and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND. The goals are to identify common biological denominators or differentiating classifiers across the continuum of ND during detectable stages of pathophysiological progression, characterize systems-based intermediate endophenotypes, validate multi-modal novel diagnostic systems biomarkers, and advance clinical intervention trial designs by utilizing systems-based intermediate endophenotypes and candidate surrogate markers. Achieving these goals is key to the ultimate development of early and effective individualized treatment of ND, such as Alzheimer’s disease. The Alzheimer Precision Medicine Initiative (APMI) and cohort program (APMI-CP), as well as the Paris based core of the Sorbonne University Clinical Research Group “Alzheimer Precision Medicine” (GRC-APM) were recently launched to facilitate the passageway from conventional clinical diagnostic and drug development toward breakthrough innovation based on the investigation of the comprehensive biological nature of aging individuals. The APMI movement is gaining momentum to systematically apply both systems neurophysiology and systems biology in exploratory translational neuroscience research on ND.
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Dates et versions

hal-01910402 , version 1 (31-10-2018)

Identifiants

Citer

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L Black, et al.. Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology. Journal of Alzheimer's Disease, 2018, 64 (s1), pp.S47 - S105. ⟨10.3233/jad-179932⟩. ⟨hal-01910402⟩
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