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Article Dans Une Revue Proceedings Année : 2017

Multiphysics Probe for Deep Brain Monitoring of Glioblastoma Environment

Charles Chatard
  • Fonction : Auteur
Olivier Pascual
Yves Jourlin
Andreï Sabac

Résumé

This work reports on the development, and preliminary results of a multiphysics probe for deep brain monitoring of neurotransmitters and metabolites in the glioblastoma environment. We made the proof of the concept of our probe with common mice glioblastoma cells GL261 modified with Green Fluorescent Protein. A silicon probe with a platinum electrode at the tip was functionalized with an enzyme in order to detect, for example, Glucose, D-serine, Lactate or Glutamate. In addition, an optical fiber was inserted in a groove in the middle of the probe for light excitation and detection of glioblastoma cells by fluorescence.

Dates et versions

hal-01917672 , version 1 (09-11-2018)

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Citer

Charles Chatard, Olivier Pascual, Yves Jourlin, Stéphane Marinesco, Daniel Barbier, et al.. Multiphysics Probe for Deep Brain Monitoring of Glioblastoma Environment. Proceedings, 2017, 1 (4), 502 (4 p.). ⟨10.3390/proceedings1040502⟩. ⟨hal-01917672⟩
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