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Article Dans Une Revue BioEssays Année : 2007

Early mouse embryo development: could epigenetics influence cell fate determination?

Résumé

It is generally assumed that the developmental program of embryogenesis relies on epigenetic mechanisms. However, a mechanistic link between epigenetic marks and cell fate decisions had not been established so far. In a recent article, Torres-Padilla and colleagues show that epigenetic information and, more precisely, histone arginine methylation mediated by CARM1 could contribute to cell fate decisions in the mouse 4-cell-stage embryo. It provides the first indications that global epigenetic information influences allocation of pluripotent cells toward the first cell lineages.

Dates et versions

hal-01934539 , version 1 (26-11-2018)

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Amandine Henckel, Szabolcs Tóth, Philippe P. Arnaud. Early mouse embryo development: could epigenetics influence cell fate determination?. BioEssays, 2007, 29 (6), pp.520 - 524. ⟨10.1002/bies.20591⟩. ⟨hal-01934539⟩
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