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Article Dans Une Revue Journal of materials chemistry‎ B Année : 2018

Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines

Résumé

β-Galactosidase has been drawing increasing attention for the treatment of lactose intolerance, but its delivery has been impeded by degradation under gastric conditions. We have demonstrated that the coating of mesoporous silica microparticles (diameter ≈ 9 µm, pore size ≈ 25 nm) with dioleoylphosphatidylcholine membranes significantly improved the loading capability and protected the enzymes from the loss of function under simulated gastric conditions. Once the particles are transferred to simulated intestinal conditions, the digestion of phosphatidylcholine with pancreatin led to the release of functional β-galactosidase. The coating of mesoporous silica nanoparticles with a single phospholipid bilayer opens up a large potential towards the controlled release of orally administrated drugs or enzymes to the intestines.

Domaines

Chimie
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Dates et versions

hal-01980676 , version 1 (14-01-2019)

Identifiants

Citer

Ileana-Alexandra Pavel, Maxime Girardon, Sarah El Hajj, Stéphane Parant, Federico Amadei, et al.. Lipid-coated mesoporous silica microparticles for the controlled delivery of β-galactosidase into intestines. Journal of materials chemistry‎ B, 2018, 6 (35), pp.5633-5639. ⟨10.1039/C8TB01114A⟩. ⟨hal-01980676⟩
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