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Article Dans Une Revue BMC Biology Année : 2018

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation

Résumé

Upon maturation in the bone marrow, polyploid megakaryocytes elongate very long and thin cytoplasmic branches called proplatelets. Proplatelets enter the sinusoids blood vessels in which platelets are ultimately released. Microtubule dynamics, bundling, sliding, and coiling, drive these dramatic morphological changes whose regulation remains poorly understood. Microtubule properties are defined by tubulin isotype composition and post-translational modification patterns. It remains unknown whether microtubule post-translational modifications occur in proplatelets and if so, whether they contribute to platelet formation.
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hal-01996730 , version 1 (25-05-2021)

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Juliette van Dijk, Guillaume Bompard, Julien Cau, Shinji Kunishima, Gabriel Rabeharivelo, et al.. Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation. BMC Biology, 2018, 16 (1), pp.116. ⟨10.1186/s12915-018-0584-6⟩. ⟨hal-01996730⟩
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