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Communication Dans Un Congrès Année : 2018

Comparison of Monte Carlo simulated physical radiation quantities for gold nanoparticles irradiated by x-rays and assessment of potential indication for targeted breast cancer treatment

Michael Beuve

Résumé

Modern radiation therapy is developing in the direction of targeted radiation treatment. Experiments in vitro and in vivo showed that gold nanoparticles (AuNPs) enhanced radiation doses to tumours in mice and pose a high potential for clinical application [1]. However, finding a selective molecular for targeting AuNPs in tumour cells is challenging. Furthermore, the enhanced energy deposited by Auger, Costa-Kronig (C-K) and secondary electrons around AuNPs is difficult to measure and it is practically simulated and estimated by application of Monte Carlo (MC) radiation transport codes. The uncertainty of cross sections of these low energy electrons used in the MC codes is large even within a same code. Uncertainty quantification of physical quantities as an output of different codes is inevitable for the establishment of biological effects and radiation doses in cellular and molecular levels. In this paper, physical quantities, e.g. electron spectra, deposited energy and absorbed dose, which are contributed from secondary electrons as well as Auger and C-K electrons released after interaction of AuNPs and x-rays are quantitatively computed and compared in a EURADOS framework. The aim is to reach a high quality assurance of radiation doses in the cellular and molecular level by applying different renowned MC codes used in nanodosimetry, such as Geant4-DNA [2], MCNP6 [3], MDM [4], NASIC [5], PARTRAC [6] and Penelope [7]. Single AuNP and multiple AuNPs in different sizes irradiated by x-rays with different energy were simulated. The quantitative absorbed doses around AuNPs can be further used for assessment of the potential use of high-Z materials in the targeted breast cancer treatment.
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Dates et versions

hal-02050756 , version 1 (27-02-2019)

Identifiants

  • HAL Id : hal-02050756 , version 1

Citer

W. B. Li, A. Belchior, Michael Beuve, M.U. Bug, S. Di Maria, et al.. Comparison of Monte Carlo simulated physical radiation quantities for gold nanoparticles irradiated by x-rays and assessment of potential indication for targeted breast cancer treatment. Third Geant4 International User Conference, Oct 2018, Bordeaux, France. ⟨hal-02050756⟩
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