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Article Dans Une Revue British Journal of Cancer Année : 2018

Influence of obesity-related risk factors in the aetiology of glioma

Stephen Chanock
Preetha Rajaraman
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Beatrice Melin
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Richard Houlston
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Résumé

BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.
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Dates et versions

hal-02149333 , version 1 (06-06-2019)

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Linden Disney-Hogg, Amit Sud, Philip J Law, Alex J Cornish, Ben Kinnersley, et al.. Influence of obesity-related risk factors in the aetiology of glioma. British Journal of Cancer, 2018, 118 (7), pp.1020-1027. ⟨10.1038/s41416-018-0009-x⟩. ⟨hal-02149333⟩
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