Anatomical and physiological foundations of cerebello-hippocampal interaction - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue eLife Année : 2019

Anatomical and physiological foundations of cerebello-hippocampal interaction

Résumé

Multiple lines of evidence suggest that functionally intact cerebello-hippocampal interactions are required for appropriate spatial processing. However, how the cerebellum anatomically and physiologically engages with the hippocampus to sustain such communication remains unknown. Using rabies virus as a retrograde transneuronal tracer in mice, we reveal that the dorsal hippocampus receives input from topographically restricted and disparate regions of the cerebellum. By simultaneously recording local field potential from both the dorsal hippocampus and anatomically connected cerebellar regions, we additionally suggest that the two structures interact, in a behaviorally dynamic manner, through subregion-specific synchronization of neuronal oscillations in the 6-12 Hz frequency range. Together, these results reveal a novel neural network macro-architecture through which we can understand how a brain region classically associated with motor control, the cerebellum, may influence hippocampal neuronal activity and related functions, such as spatial navigation.
Fichier principal
Vignette du fichier
elife-41896-v1.pdf (5.44 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02172192 , version 1 (03-07-2019)

Identifiants

Citer

Thomas Charles Watson, Pauline Obiang, Arturo Torres-Herraez, Aurélie Watilliaux, Patrice Coulon, et al.. Anatomical and physiological foundations of cerebello-hippocampal interaction. eLife, 2019, 8, pp.e41896. ⟨10.7554/eLife.41896⟩. ⟨hal-02172192⟩
93 Consultations
98 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More