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Article Dans Une Revue Oncogene Année : 2012

Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL

A. E. Sayan
  • Fonction : Auteur
R. Stanford
  • Fonction : Auteur
R. Vickery
  • Fonction : Auteur
E. Grigorenko
J. Diesch
  • Fonction : Auteur
K. Kulbicki
  • Fonction : Auteur
R. Edwards
  • Fonction : Auteur
R. Pal
  • Fonction : Auteur
P. Greaves
  • Fonction : Auteur
I. Jariel-Encontre
  • Fonction : Auteur
M. Kriajevska
  • Fonction : Auteur
J. K. Mellon
  • Fonction : Auteur
A. S. Dhillon
  • Fonction : Auteur
E. Tulchinsky
  • Fonction : Auteur

Résumé

Fos-related antigen 1 (Fra-1) is a Fos family member overexpressed in several types of human cancers. Here, we report that Fra-1 is highly expressed in the muscle-invasive form of the carcinoma of the bladder (80%) and to a lesser extent in superficial bladder cancer (42%). We demonstrate that in this type of cancer Fra-1 is regulated via a C-terminal instability signal and C-terminal phosphorylation. We show that manipulation of Fra-1 expression levels in bladder cancer cell lines affects cell morphology, motility and proliferation. The gene coding for AXL tyrosine kinase is directly upregulated by Fra-1 in bladder cancer and in other cell lines. Importantly, our data demonstrate that AXL mediates the effect of Fra-1 on tumour cell motility but not on cell proliferation. We suggest that AXL may represent an attractive therapeutic target in cancers expressing high Fra-1 levels.

Dates et versions

hal-02193074 , version 1 (24-07-2019)

Identifiants

Citer

A. E. Sayan, R. Stanford, R. Vickery, E. Grigorenko, J. Diesch, et al.. Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL. Oncogene, 2012, 31 (12), pp.1493--503. ⟨10.1038/onc.2011.336⟩. ⟨hal-02193074⟩
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