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Article Dans Une Revue Journal of Controlled Release Année : 2013

Multifunctional polymersomes for cancer theranostics

Résumé

The concept of personalized medicine is drawing a lot of attention, pointing out the future for medical and pharmaceutical practices, where synthetic nanovectors could be considered as interesting tools. First generation vectors have proved their ability to reduce deleterious side effects, especially in cancer therapy. But the current trend aims at the elaboration of nanovectors that will be able to cross biological barriers, bind to the diseased site, release a drug in a controlled manner and act as an imaging agent for both diagnosis and treatment follow-up [1]. Thanks to their unique features, polymersomes have shown, in a relatively short period of time, their potential as both therapeutic and imaging tools and appear especially suited for the elaboration of multifunctional carriers. Here, we describe the production, characterization and evaluation in vitro and in vivo of a multicomponent, targeted polymersome system, focusing in a bone metastasis model (from breast cancer). Non-toxic, bioresorbable, amphiphilic block copolymer, poly(trimethylene carbonate)-b-poly(γ-benzyl-l-glutamate), forming polymersomes upon self-assembly, was functionalized using a hetero-bifunctional oligo(ethylene glycol) linker allowing the covalent grafting of antibodies targeting the HER2 receptor. A versatile strategy allowed the preparation in two steps of polymersomes loaded with both anticancer drug and magnetic iron oxide nanoparticles [2] and bearing antibodies at their surface. Efficient and selective targeting of HER2 expressing cells was demonstrated with these polymersomes (Fig. 1). They also elicited good properties as contrast agents for MRI and the drug release was triggered under magnetic hyperthermia, showing that these systems are promising tools for theranostic applications.
Thevenot et al JCR2013 proceedings abstract JCR2013_172_e44-45.pdf (1.13 Mo) Télécharger le fichier
Origine : Accord explicite pour ce dépôt
Commentaire : Abstract of the 2nd Symposium on Innovative Polymers for Controlled Delivery (SIPCD 2012), 11–14 September 2012, Suzhou, China, Edited by Wim Hennink, Zhiyuan Zhong and Jan Feijen

Dates et versions

hal-02202462 , version 1 (01-08-2019)

Identifiants

Citer

Julie Thévenot, Hugo de Oliveira, Olivier Sandre, Line Pourtau, Encarnacion Andrés, et al.. Multifunctional polymersomes for cancer theranostics. Journal of Controlled Release, 2013, 172 (1), pp.e44-e45. ⟨10.1016/j.jconrel.2013.08.094⟩. ⟨hal-02202462⟩
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