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Article Dans Une Revue Circulation. Heart failure Année : 2019

Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure

1 DCAC - Défaillance Cardiovasculaire Aiguë et Chronique
2 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]
3 INI-CRCT - Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy]
4 Cardiovascular & Renal Clinical Trialists - CRCT - French-Clinical Research Infrastructure Network - F-CRIN [Paris]
5 Universidade do Porto = University of Porto
6 CARIM - Cardiovascular Research Institute Maastricht
7 MUMC - Maastricht University Medical Centre
8 LSHTM - London School of Hygiene and Tropical Medicine
9 IBENS - Institut de biologie de l'ENS Paris
10 Institute for Molecular and Translational Therapeutic Strategies - IMTTS [Hannover, Germany]
11 Institute of Health and Wellbeing
12 University of Glasgow
13 CIMA - Center for Applied Medical Research [Plamplona]
14 Institute of Health Carlos III
15 IdiSNA - Instituto de Investigación Sanitaria de Navarra
16 University Clinic of Navarra
17 TATAA Biocenter AB
18 Casa di Cura Quisisana
19 Institute of Cardiovascular and Medical Sciences [Glasgow]
20 UMMC - University of Mississippi Medical Center
21 MHH - Medizinische Hochschule Hannover = Hannover Medical School
22 Hull York Medical School
23 LUMC - Leiden University Medical Center
24 IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri" [Milan, Italy]
25 ACS Biomarker
26 Framingham Heart Study
27 UPD7 - Université Paris Diderot - Paris 7
28 Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]
29 Mosaiques Diagnostics GmbH [Hannover, Germany]
30 RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
31 Imperial College London
32 Department of Cardiovascular Sciences [Leuven]
33 IMTTS - Institute of Molecular and Translational Therapeutic Strategies
Ping Wang
  • Fonction : Auteur
  • PersonId : 985666
Joost Leenders
  • Fonction : Auteur
Peter Sever
  • Fonction : Auteur
  • PersonId : 887655
Jan Staessen
  • Fonction : Auteur
  • PersonId : 928256

Résumé

Background Identifying the mechanistic pathways potentially associated with incident heart failure (HF) may provide a basis for novel preventive strategies. Methods and Results To identify proteomic biomarkers and the potential underlying mechanistic pathways that may be associated with incident HF defined as the first hospitalization for HF, a nested-matched case-control design was used with cases (incident HF) and controls (without HF) selected from 3 cohorts (>20 000 individuals). Controls were matched on cohort, follow-up time, age, and sex. Two independent sample sets (a discovery set with 286 cases and 591 controls and a replication set with 276 cases and 280 controls) were used to discover and replicate the findings. Two hundred fifty-two circulating proteins in the plasma were studied. Adjusting for the matching variables age, sex, and follow-up time (and correcting for multiplicity of tests), 89 proteins were found to be associated with incident HF in the discovery phase, of which 38 were also associated with incident HF in the replication phase. These 38 proteins pointed to 4 main network clusters underlying incident HF: (1) inflammation and apoptosis, indicated by the expression of the TNF (tumor necrosis factor)-family members; (2) extracellular matrix remodeling, angiogenesis and growth, indicated by the expression of proteins associated with collagen metabolism, endothelial function, and vascular homeostasis; (3) blood pressure regulation, indicated by the expression of natriuretic peptides and proteins related to the renin-angiotensin-aldosterone system; and (4) metabolism, associated with cholesterol and atherosclerosis. Conclusions Clusters of biomarkers associated with mechanistic pathways leading to HF were identified linking inflammation, apoptosis, vascular function, matrix remodeling, blood pressure control, and metabolism. These findings provide important insight on the pathophysiological mechanisms leading to HF. Clinical Trial Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT02556450.
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Origine : Publication financée par une institution
Licence : CC BY - Paternité

Dates et versions

hal-02267410 , version 1 (08-12-2023)

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Paternité

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João Pedro Ferreira, Job Verdonschot, Timothy Collier, Ping Wang, Anne Pizard, et al.. Proteomic Bioprofiles and Mechanistic Pathways of Progression to Heart Failure. Circulation. Heart failure, 2019, 12 (5), pp.e005897. ⟨10.1161/CIRCHEARTFAILURE.118.005897⟩. ⟨hal-02267410⟩
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