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Article Dans Une Revue Cell Death and Differentiation Année : 2014

Liver X Receptor β activation induces pyroptosis of human and murine colon cancer cells

Résumé

Liver X receptors (LXRs) have been proposed to have some anticancer properties, through molecular mechanisms that remain elusive. Here we report for the first time that LXR ligands induce caspase-1-dependent cell death of colon cancer cells. Caspase-1 activation requires Nod-like-receptor pyrin domain containing 3 (NLRP3) inflammasome and ATP-mediated P2 × 7 receptor activation. Surprisingly, LXRβ is mainly located in the cytoplasm and has a non-genomic role by interacting with pannexin 1 leading to ATP secretion. Finally, LXR ligands have an antitumoral effect in a mouse colon cancer model, dependent on the presence of LXRβ, pannexin 1, NLRP3 and caspase-1 within the tumor cells. Our results demonstrate that LXRβ, through pannexin 1 interaction, can specifically induce caspase-1-dependent colon cancer cell death by pyroptosis.
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Dates et versions

hal-02300412 , version 1 (29-09-2019)

Identifiants

  • HAL Id : hal-02300412 , version 1

Citer

Valentin Derangere, Angélique Chevriaux, F Courtaut, Melanie Bruchard, H Berger, et al.. Liver X Receptor β activation induces pyroptosis of human and murine colon cancer cells. Cell Death and Differentiation, 2014, 21, pp.1914 - 1924. ⟨hal-02300412⟩
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