Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Chemical Communications Année : 2012

Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins

Résumé

The double addition of Grignard (alkyl, aryl, alkenyl, alkynyl) reagents to acyl cyanohydrins was performed under unusually smooth conditions with a concomitant O–N acyl transfer, providing a very simple and general access to α,α,α-trisubstituted amides.

Domaines

Chimie organique
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Dates et versions

hal-00752112 , version 1 (14-11-2012)

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Citer

Fatma Boukattaya, Andrii Stanovych, Paul Setzer, Souhir Abid, Houcine Ammar, et al.. Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins. Chemical Communications, 2012, 48 (69), pp.8655-8657. ⟨10.1039/c2cc34841a⟩. ⟨hal-00752112⟩
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