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Article Dans Une Revue Clinical Epigenetics Année : 2019

Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Stéphane Audebert
François Bertucci

Résumé

Background: The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular, functional, and prognosis significance of this epigenetic alteration named H3K27me3 HIST1 in NPM1-mutated (NPM1mut) CN-AML.
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hal-02322283 , version 1 (13-12-2019)

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Sylvain Garciaz, Lia N’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, et al.. Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation. Clinical Epigenetics, 2019, 11 (1), ⟨10.1186/s13148-019-0738-6⟩. ⟨hal-02322283⟩
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