The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue BMC Complementary and Alternative Medicine Année : 2018

The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins

Résumé

Background: Phyllanthus amarus (Schum & Thonn), a plant belonging to the family of Euphorbiaceae is used in Ivorian traditional medicine to treat cardiovascular disorders such as hypertension. However, although this plant has been described as a diuretic agent, the underlying mechanism remains unclear. Therefore, the aim of the present study was to investigate the mechanism action of diuretic effects of an ethanolic fraction of Phyllanthus amarus (EFPA) in rats. Methods: Effects of EFPA on urinary excretion were carried out for doses ranging from 5 to 80 mg/kg given by intraperitoneal injection (i.p.) and compared with that induced by furosemide (5 mg/kg) after 8 h. Thereafter, the diuretic activity of EFPA was also evaluated in the presence of indomethacin (5 mg/kg, i.p.) in order to determine the involvement of prostaglandins, after 24 h. Results: Between 5 and 80 mg/kg, EFPA induced a significant urinary excretion. The profile of urinary excretion showed that after 2 h, the highest dose of 80 mg/kg induced a urinary volumetric excretion (UVE), which was similar to that induced by furosemide. After 24 h, EFPA at 10 mg/kg increased significantly UVE, Na + (43 mEq) and Cl¯(97 mEq) urinary excretions without promoting kaliuresis. In rats pretreated with indomethacin, the urinary excretion and the natriuretic response of EFPA were significantly reduced. Conclusion: Altogether, this study has shown that EFPA promotes a significant urinary excretion of water and Na + , confirming its diuretic activity. Moreover, the increased diuresis could be attributed, at least in part, to the involvement of prostaglandins.

Domaines

Pharmacologie
Fichier principal
Vignette du fichier
12906_2018_Article_2158.pdf (491.63 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02322492 , version 1 (21-10-2019)

Identifiants

Citer

Alain N'Guessan Yao, Mamadou Kamagaté, Augustin Kouao Amonkan, Philippe Chabert, Fidèle Kpahé, et al.. The acute diuretic effect of an ethanolic fraction of Phyllanthus amarus (Euphorbiaceae) in rats involves prostaglandins. BMC Complementary and Alternative Medicine, 2018, 18 (1), ⟨10.1186/s12906-018-2158-0⟩. ⟨hal-02322492⟩
77 Consultations
61 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More