Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Cells Année : 2019

Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches

Damien Jeandard
  • Fonction : Auteur
  • PersonId : 1056651
Anna Smirnova
  • Fonction : Auteur
  • PersonId : 1056652
Eric Barrey
Alexandre Smirnov

Résumé

Mitochondria harbor their own genetic system, yet critically depend on the import of a number of nuclear-encoded macromolecules to ensure their expression. In all eukaryotes, selected non-coding RNAs produced from the nuclear genome are partially redirected into the mitochondria, where they participate in gene expression. Therefore, the mitochondrial RNome represents an intricate mixture of the intrinsic transcriptome and the extrinsic RNA importome. In this review, we summarize and critically analyze data on the nuclear-encoded transcripts detected in human mitochondria and outline the proposed molecular mechanisms of their mitochondrial import. Special attention is given to the various experimental approaches used to study the mitochondrial RNome, including some recently developed genome-wide and in situ techniques.
Fichier principal
Vignette du fichier
Cells 2019.pdf (4.34 Mo) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02328408 , version 1 (23-10-2019)

Licence

Paternité

Identifiants

Citer

Damien Jeandard, Anna Smirnova, Ivan Tarassov, Eric Barrey, Alexandre Smirnov, et al.. Import of Non-Coding RNAs into Human Mitochondria: A Critical Review and Emerging Approaches. Cells, 2019, 8 (3), pp.286. ⟨10.3390/cells8030286⟩. ⟨hal-02328408⟩
65 Consultations
42 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More