The invasive proteome of glioblastoma revealed by laser-capture microdissection - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Neuro-Oncology Advances Année : 2019

The invasive proteome of glioblastoma revealed by laser-capture microdissection

Justine Rudewicz
Rolf Bjerkvig

Résumé

Background. Glioblastomas are heterogeneous tumors composed of a necrotic and tumor core and an invasive periphery. Methods. Here, we performed a proteomics analysis of laser-capture micro-dissected glioblastoma core and invasive areas of patient-derived xenografts. Results. Bioinformatics analysis identified enriched proteins in central and invasive tumor areas. Novel markers of invasion were identified, the genes proteolipid protein 1 (PLP1) and Dynamin-1 (DNM1), which were subsequently validated in tumors and by functional assays. Conclusions. In summary, our results identify new networks and molecules that may play an important role in glioblastoma development and may constitute potential novel therapeutic targets.
Fichier principal
Vignette du fichier
vdz029.pdf (1.28 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-02347439 , version 1 (09-12-2020)

Identifiants

Citer

Thomas Daubon, Joris Guyon, Anne-Aurélie Raymond, Benjamin Dartigues, Justine Rudewicz, et al.. The invasive proteome of glioblastoma revealed by laser-capture microdissection. Neuro-Oncology Advances, 2019, 1 (1), pp.1-12. ⟨10.1093/noajnl/vdz029⟩. ⟨hal-02347439⟩
149 Consultations
69 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More