Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice - CNRS - Centre national de la recherche scientifique Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2019

Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice

Résumé

Cigarette smoke exposure is a leading cause of chronic obstructive pulmonary disease (COPD), a major health issue characterized by airway inflammation with fibrosis and emphysema. Here we demonstrate that acute exposure to cigarette smoke causes respiratory barrier damage with the release of self-dsDNA in mice. This triggers the DNA sensor cGAS (cyclic GMP-AMP synthase) and stimulator of interferon genes (STING), driving type I interferon (IFN I) dependent lung inflammation, which are attenuated in cGAS, STING or type I interferon receptor (IFNAR) deficient mice. Therefore, we demonstrate a critical role of self-dsDNA release and of the cGAS-STING-type I interferon pathway upon cigarette smoke-induced damage, which may lead to therapeutic targets in COPD.
Fichier principal
Vignette du fichier
Nascimento_SciRep2019_s41598-019-51427-y.pdf (2.56 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02354641 , version 1 (16-11-2020)

Licence

Paternité

Identifiants

Citer

Mégane Nascimento, Aurélie Gombault, Norinne Lacerda-Queiroz, Corinne Panek, Florence Savigny, et al.. Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-51427-y⟩. ⟨hal-02354641⟩

Collections

CNRS UNIV-ORLEANS
62 Consultations
48 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More