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Article Dans Une Revue Developmental Cell Année : 2019

Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs

Résumé

Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non-visual fields. We discover that changes in the temporal regulation of the highly conserved eyeless/Pax6 gene expression during development is a conserved mechanism for sensory trade-offs within and between Drosophila species. We identify a natural single nucleotide polymorphism in the cis-regulatory region of eyeless in a binding site of its repressor Cut that is sufficient to alter its temporal regulation and eye size. Because eyeless/Pax6 is a conserved regulator of head sensory placode subdivision, we propose that its temporal regulation is key to define the relative size of head sensory organs.
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hal-02359426 , version 1 (20-07-2022)

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Ariane Ramaekers, Annelies Claeys, Martin Kapun, Emmanuele Mouchel-Vielh, Delphine Potier, et al.. Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs. Developmental Cell, 2019, 50 (6), pp.780+. ⟨10.1016/j.devcel.2019.07.027⟩. ⟨hal-02359426⟩
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