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Article Dans Une Revue New Journal of Chemistry Année : 2019

Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity

Résumé

New bis(α-aminophosphonates) were directly prepared with high diastereoselectivity by lipase catalytic promiscuity in the presence of immobilized Candida antarctica lipase. We focused on the multi-component Kabachnik–Fields reaction using various aldehydes, benzidine, and diethylphosphite in one pot. The reaction proceeded with short reaction times with good to excellent yields. The CAL-B was easily recovered and reused several times. A total diastereoselectivity was observed for bis(α-aminophosphonates) 4a, 4c, 4h, 4i, 4k and was high for 4b, 4f and 4j.
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Dates et versions

hal-02359964 , version 1 (28-07-2021)

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Rim Aissa, Samia Guezane-Lakoud, Emilie Kolodziej, Martial Toffano, Louisa Aribi-Zouioueche. Diastereoselective synthesis of bis(α-aminophosphonates) by lipase catalytic promiscuity. New Journal of Chemistry, 2019, 43 (21), pp.8153-8159. ⟨10.1039/c8nj06235h⟩. ⟨hal-02359964⟩
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