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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2020

N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands

Résumé

Sphingolipids (SLs) are essential constituents of the cell membranes that also play a major role in signaling processes, notably in relation with cell growth, differentiation and apoptosis. 1 The metabolism of SLs is finely regulated by a network of highly compartmentalized, yet interdependent, enzymatic pathways centered on the pivotal metabolite ceramide (Cer). The complexity of this metabolism is also due to the specific subcellular localization of the corresponding enzymes, correlated to the marked hydrophobicity of most of the Cer derivatives. 1 The conjunction of these two characteristics calls for specific transport mechanisms to transfer SLs between organelles' membranes. Thus, Cer generated on the cytosolic side of the endoplasmic reticulum (ER) has to be delivered to the trans-Golgi region to be further metabolized. In particular, Cer conversion into sphingomyelin (SM) relies on the selective trafficking operated by the ceramide transport protein CERT. 2

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Dates et versions

hal-02362770 , version 1 (02-12-2020)

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Tessa Castellan, Cécile Santos, Frédéric Rodriguez, Mathieu L Lepage, Yan Liang, et al.. N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands. Bioorganic and Medicinal Chemistry Letters, 2020, pp.126796. ⟨10.1016/j.bmcl.2019.126796⟩. ⟨hal-02362770⟩
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