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Article Dans Une Revue Neuropharmacology Année : 2019

Atomoxetine improves attentional orienting in a predictive context

Résumé

• Atomoxetine decreases reaction time of the most prevalent trials. • Atomoxetine modulates the accumulation rate of sensory information. • Atomoxetine adapts the response strategy to the context. The role of norepinephrine (NE) in visuo-spatial attention remains poorly understood. Our goal was to identify the attentional processes influenced by atomoxetine (ATX) injections, a NE-reuptake inhibitor that boosts the level of NE in the brain, and to characterize these influences. We tested the effects of ATX injections, on seven monkeys performing a saccadic cued task in which cues and distractors were used to manipulate spatial attention. We found that when the cue accurately predicted the location of the upcoming cue in 80% of the trials, ATX consistently improved attentional orienting, as measured from reaction times (RTs). These effects were best accounted for by a faster accumulation rate in the valid trials, rather than by a change in the decision threshold. By contrast, the effect of ATX on alerting and distractor interference was more inconsistent. Finally, we also found that, under ATX, RTs to non-cued targets were longer when these were presented separately from cued targets. This suggests that the impact of NE on visuo-spatial attention depends on the context, such that the adaptive changes elicited by the highly informative value of the cues in the most frequent trials were accompanied by a cost in the less frequent trials.
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Dates et versions

hal-02375786 , version 1 (22-11-2019)

Identifiants

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Amélie Reynaud, Mathilda Froesel, Carole Guedj, Sameh Ben Hadj Hassen, Justine Cléry, et al.. Atomoxetine improves attentional orienting in a predictive context. Neuropharmacology, 2019, 150, pp.59-69. ⟨10.1016/j.neuropharm.2019.03.012⟩. ⟨hal-02375786⟩
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